Worksheet VI: The Brain

1. The thickening along the dorsal length of a 17 day embryo is called the __a__. This __a__  gives rise to all neurons and most neuroglial cells. The midline of the __a__ invaginates to become the __b__ while the sides of the __a__ grow upward and over to become __c__.  As the __c__ meet, the __b__ becomes the __d__.  Most of the PNS comes from the __c__.  During the 3rd to 4th weeks of embryological development, the anterior end of the __d__ forms 3 distinct swellings, a forebrain called the __e__, a midbrain called the __f__, and a hindbrain called the __g__.  By the 5th week of development the __e__ divides into an anterior section called the __h__ and a posterior section called the __i__.  The __f__ remains undivided while the __g__ divides into an anterior section named the __j__ and a posterior section called the __k__.  The __l__ includes the __f__, __j__ without the cerebellum, and the __k__.
    a. ____________________________        g. ___________________________
    b. ____________________________        h. ____________________________
    c. ____________________________        i. ____________________________
    d. ____________________________        j. ___________________________
    e. ____________________________        k. ___________________________
    f. _____________________________    l. ____________________________
2. Identify the protective coverings and spaces of the brain based on the descriptions given below.    
    a.  Innermost meninx; soft mother.            _____________________________
    b. Bony covering of brain.                _____________________________
    c. Separation between meningeal and periosteal layers.    ____________________________
    d. Composed of meningeal and periosteal layers.    _____________________________
    e.   Space between dura mater and arachnoid; contains
    serous fluid.                        _____________________________
    f. Middle meninx and net-like.                _____________________________
    g. Meninx that forms falx cerebri and cerebelli.        _____________________________
    h. Meninx that forms tentorium cerebelli.            _____________________________
    i. Space that contains cerebrospinal fluid outside of brain.___________________________
    j.  Penetrates into longitudinal fissue; part of dura mater.    ___________________________   
   k.  Penetrates into transverse fissure; part of dura mater.    __________________________  
   l.  Extensions of arachnoid meninx into dural sinuses.    _____________________________
    m.  Highly vascular and nourishes underlying cells of
    brain and cord.                        _____________________________
    n. Outermost meninx.                    _____________________________
    o.  Formed from pia mater; secretes CSF.        _____________________________
    p.  Lymph-like fluid forms protective cushion around brain. __________________________
    q.  Dura mater that partitions right and left cerebellar
    hemispheres.                        _____________________________
    r.  Layer of dura mater that adheres to bone.        _____________________________   
   s. Inner layer of dura mater.                _____________________________
3. Name the meninges and spaces surrounding the brain from outermost to innermost.
                                _____________________________
                                _____________________________
                                _____________________________
                                _____________________________
                                _____________________________
4. Inflammation of the meninges is called:            _____________________________
5.  List 3 functions of cerebrospinal fluid.               
                                _____________________________
                                _____________________________
                                _____________________________

6.  Cerebrospinal fluid is formed by the __a__ and reabsorbed in the __b__.  CSF  circulates around the brain in the __c__ space and inside the brain in __d__ (number) chambers called __e__.  Two of these chambers are inside the __f__ hemispheres and are called __g__.  These 2 chambers are connected to the third chamber, called the __h__, by the __i__ foramen.  The __h__ forms the midplane of the __j__. Finally, the  last chamber, called the __k__, is connected to the third chamber by the __l__.  This last chamber, located mostly in the __m__,  is continuous with the __n__ of the spinal cord.
    a. ____________________________        h. ___________________________
    b. ____________________________        i. ____________________________
    c. ____________________________        j. ____________________________
    d. ____________________________        k. ___________________________
    e. ____________________________        l. ____________________________    
    f. _____________________________     m. ___________________________
    g. ____________________________        n. ___________________________
7.  CSF contains __a__ (more/less) Na+, __b__ (more/less) glucose, __c__ (more/less) Cl-, __d__ (more/less) Ca++, __e__ (more/less) Mg, __f__ (more/less) K, __g__ (more/less) H+ than plasma.
    a. ____________________________        e. ___________________________
    b. ____________________________        f. ____________________________
    c. ____________________________        g. ____________________________
    d. ____________________________        
8. Identify 3 contributing structures to the blood-brain barrier.    
                                _____________________________
                                _____________________________
                                _____________________________
9.  Name 2 functions of the blood-brain barrier.          
                                 _____________________________
                                _____________________________
10.   Name 3 substances that pass through the blood-brain barrier easily and 3 substances that are very restricted.
                Restricted                        Permeable
    ______________________________        _____________________________
    ______________________________        _____________________________   
    ______________________________        _____________________________

11.  Name the 5 lobes of the telencephalon.           
                                _____________________________
                                _____________________________
                                _____________________________
                                _____________________________
                                _____________________________
12.  The cerebrum has 2 areas of gray matter, an outer region called the _____________________ and 2 large inner clusters of gray matter called the _______________________.
13. Deep indentations on the brain's surface are called:    _____________________________.
14. Shallow indentations on the brain's surface are called:    _____________________________.
15. Elevated ridges or folds of the cerebrum are called:    _____________________________.
16.  The sulcus that separates the frontal from parietal lobes is the:__________________________.
17.  The right and left hemispheres of the brain are connected by the:________________________.
18.  The ___________________ sulcus separates frontal and temporal lobes.
19.  The ____________________ fissure separates the 2 cerebral hemispheres.
20. The _____________________ fissure separates the cerebrum from the cerebellum.
21. Identify the lobe of the cerebrum based on the descriptions given below.
    a. Houses Wernick's area.                ____________________________
    b. Precentral gyrus.                    ____________________________
    c. Postcentral gyrus.                    ____________________________
    d. Broca's area.                        ____________________________
    e. Premotor cortex.                    ____________________________
    f.  Auditory centers and visual memories here.        ____________________________
    g. Possibly controls gastrointestinal activity.        ____________________________
    h. Primary motor cortex.                    ____________________________
    i. Somatosensory region.                ____________________________    
    j. Prefrontal cortex.                    ____________________________
    k.  Lobe deep to lateral sulcus.                ____________________________
    l.  Coordinates eye muscles, visual cortex.        ____________________________
    m. Posteriormost lobe.                    ____________________________
    n. Anteriormost lobe.                    ____________________________
22.  Identify the embryonic brain region (telencephalon, diencephalon, etc.) housing the structures listed below.  
    a. Medulla oblongata.                    ____________________________
    b. Hypothalamaus.                    ____________________________  
    c. Pineal gland.                        ____________________________
    d. Lateral ventricles.                    ____________________________
    e. Superior and inferior colliculi.                ____________________________
    f. Cerebral cortex and cerebral nuclei.            ____________________________
    g. Olive and pyramids.                    ____________________________
    h. Cerebellum                        ____________________________
    i. Pons.                            ____________________________
    j. Cerebral peduncles.                    ____________________________
    k. Third ventricle.                    ____________________________
    l. Red nucleus and substantia nigra.            ____________________________
    m. Corpus callosum.                    ____________________________
    n. Corpus striatum.                    ____________________________
    o.  Central sulcus.                    ____________________________
    p. Vermis.                        ____________________________
    q. Arbor vitae.                        ____________________________
    r.  Corpora quadrigemina.                ____________________________
    s. Thalamus and epithalamus.                ____________________________
    t.  Broca's area.                        ____________________________
    u. Association fibers.                    ____________________________
    v.  Insula.                        ____________________________
    w. Decussation of pyramids.                ____________________________
    x.  Mammillary bodies.                    ____________________________
    y. Nucleus cuneatus and gracilis.            ____________________________   
    z. Pituitary gland.                    ____________________________
23.  Identify the brain area that is specifically associated with the function(s) given below.
    a.  Relay and filtering center of the brain.            ____________________________
    b. Learned motor skills that are repititous; e.g. typing
    playing an instrument, etc.                ____________________________
    c.  Autonomic NS control center.            ____________________________
    d. Coordinates muscle activity; maintains postural
    adjustments.                        ____________________________
    e. Conscious control of skeletal muscles.        ____________________________
    f.  Motor speech area; coordinates muscles of larynx
    and pharynx with respiratory muscles.            ____________________________
    g.  Contains respiratory control centers known as
    apneustic and pneumotaxic centers.            ____________________________
    h.  Sensory area that responds to cutaneous and muscle
    receptors.                        ____________________________
     i.  Thought, intelligence, learning, motivation, personality. ___________________________
    j.  Abstract ideas, judgement, conscience.        ____________________________    
    k. Understanding speech, verbal articulation of thoughts
    and emotions, interprets textures and shapes of objects. __________________________
    l.  Receives info from auditory and visual centers and
    allows comprehension of written and spoken language. ____________________________
    m.  Area responsible for visual reflexes.            ____________________________
    n. Area responsible for auditory reflexes.        ____________________________
    o. Area responsible for licking and swallowing reflexes.____________________________
     p.  Cardiovascular regulation, body-temperature regulation,
     regulation of water and electrolyte balance, regulation of
    hunger and control of gastrointestinal activity, regulation
    of sleeping and wakefulness, sexual response, and
    emotions.                                                    ___________________________
    q. Secretes hormones that control and regulate
    activities of other glands.                ___________________________
    r.  Allow cerebellum to communicate with lower brain
    and spinal cord.                        ___________________________
24. List 4 functions attributed to the right brain and 4 functions for the left brain.
    _____________________________            _____________________________
    _____________________________            _____________________________
    _____________________________            _____________________________
    _____________________________            _____________________________
25.  The collective electrical action of millions of neurons in the brain gives a graphical recording called the:  _____________________________.
26.  __a__ fibers include ascending and descending tracts that transmit impulses between the cerebrum and other brain parts and the spinal cord.  __b__ fibers conduct impulses between neurons in each cerebral hemisphere. __c__ fibers, such as the corpus callosum and anterior commissure, allow communication between hemispheres.               
                                a. __________________________
                                b. __________________________
                                c. __________________________
27.  The red nucleus and substantia nigra are structurally part of the __a__, but functionally part of the __b__.                               
                                a. __________________________
                                b. __________________________
28. Name the 3 parts of the diencephalon.           
                                ____________________________
                                ____________________________
                                ____________________________
29. The cone-shaped mass that extends outward from the posterior end of the epithalamus is called the:  ____________________________.
30.  The pituitary gland, or __a__, is attached to the base of the hypothalamus by a stalk called the __b__.  It sits in the __c__ of the sphenoid bone and is divided into 2 distinct glands called the __d__ and __e__.  The __d__ is a physical extension of the hypothalamus while the __e__ is derived from nonnervous tissue.
    a. ____________________________        d. ____________________________
    b. ____________________________        e. ____________________________
    c. ____________________________
31. Four rounded elevations on the dorsal surface of the midbrain are collectively called the:
                                ____________________________.
32. The 2 major parts of the metencephalon are the __________________________ and ________________________.

33.  The cerebellum is separated from the cerebrum by the __a__ fissure.  The two cerebellar hemispheres are united by the middle __b__.  The outer gray matter is called the __c__ while the inner white matter is referred to as the __d__.  The cerebellum communicates with the midbrain and other superior brain areas by the __e__; with the pons by the __f__; and with the medulla and spinal cord by the __g__.
    a. ____________________________        e. ____________________________
    b. ____________________________        f. ____________________________
    c. ____________________________        g. ____________________________
    d. ____________________________
34.  Jerky and uncoordinated movements are referred to as:    ____________________________.
35.   The pyramids house ___________________ (motor/sensory) tracts.
36. Enlargements on the lateral surface of the medulla that serve as relay centers for information headed to cerebellar cortex from spinal cord are the:        ____________________________

37. Name 5 nuclei found in the medulla and give a function for each.
                                ____________________________
                                ____________________________
                                ____________________________
                                ____________________________
38. Portions of this system are located in the spinal cord, pons, midbrain, thalamus, and hypothalamus. This system arouses and keeps the cerebrum alert, monitors sensory information received by cerebrum, helps the cerebellum activate certain motor units to maintain muscle tone and coordinate skeletal muscle contractions.                            ____________________________
39. Portions of this system are found in the cerebral cortex, hypothalamus, hippocampus, and amygdaloid nucleus. It is known as the emotional brain because it links smells with emotional events and prevents us from acting out our emotions.                    ____________________________
40. This system is responsible for our sleep-wake cycle.    ____________________________
41. What are pyramidal tracts and what do they control? _________________________________
____________________________________________________________________________
____________________________________________________________________________
42. Why do stroke victims often have paralysis on the opposite side of their bodies from where the damage is in their brains? _________________________________________________________
____________________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________
43. Describe how the central canal and ventricles form during embryological development. Please use drawings._____________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________




44. Describe how the 5 embryonic brain regions form after the closure of the neural folds. ______
____________________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________




45. What happens when neurons of the substantia nigra are damaged and cannot release dopamine to the cerebral nuclei? _____________________________________________________________
____________________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________


46. A patient comes to you that through a variety of tests can clearly understand written and spoken language, but cannot verbalize his thoughts.  What area of the brain might be affected? _________
____________________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________
____________________________________________________________________________