Worksheet V:  Lymphatic System

1.   List the 2 major components of the lymphatic system.    _______________________________
                                                                                              _______________________________

2.  Give 3 functions of the lymphatic system.    ____________________________________________
                                                                          ____________________________________________
                                                                          ____________________________________________

3. List 5 structures without lymph vessels.            _______________________________
                                                                              _______________________________
                                                                              _______________________________
                                                                              _______________________________
                                                                              _______________________________

4.  Interstitial fluid that enters lymph vessels is called __a__.  These fluids are lost from the __b__ (arterial/venule)
end of the capillary because of __c__ pressure.
    a. ______________________________        c. ______________________________
    b. ______________________________

5.  List the 4 categories of lymphatic vessels that lymph passes through from the time it is first formed until it returns
to the main circulation.                                                                           
                                _______________________________
                                _______________________________
                                _______________________________
                                _______________________________

6.  Interstitial fluid, that leaks from true capillaries, is captured by __a__ for its return to the main circulation.  These
__a__ are composed of loosely joined __b__ cells that act as __c__.  Increased pressure forces open these __c__ and
more interstitial is collected by __a__.  __a__ found in the intestinal villi are called __d__ and the lymph in these
vessels is __e__ (Give color.) because of its high __f__ content.  __a__ unite into __g__.  __g__ have the same 3
tunics as veins and travel next to major arteries.  __g__ unite to form larger vessels called __h__.  These __h__ drain
various body regions such as the lumbar, intestinal, and subclavian regions.  __h__ merge to form the 2 largest vessels
of the lymphatic system called the __i__ and __j__.  The __i__ drains lymph from the upper arm, right side of the head
and thorax while the __j__ receives lymph from the rest of the body.  The __j__ arises as a large sac anterior to the
second lumbar vertebrae.  This large sac is called the __k__.  Lymph is returned to the main circulation at the junction
of the __l__ (Give vein.) and the __m__ (Give vein.) on both sides of the body.
    a. ______________________________        h. ______________________________
    b. ______________________________        i. ______________________________
    c. ______________________________        j. ______________________________
    d. ______________________________        k. ______________________________
    e. ______________________________        l. ______________________________
    f. ______________________________        m. ______________________________
    g. ______________________________

7.  Lymph is transported in lymphatic vessels in a similar manner to the way blood is transported by veins.
List 4 of these similarities.                _____________________________________
                                                         _____________________________________
                                                         _____________________________________
                                                         _____________________________________

8.  There are __a__ (Give approximate number.) of lymph nodes scattered throughout the body.  Two large
clusters are found in the __b__ and __c__ regions of the body.
    a. ______________________________        c. ______________________________
    b. ______________________________    

9.  Identify the parts or cells in a lymph node based on the information given below.
    a. Central, innermost, region of lymph node.            ______________________________   
    b. Outer region; with densely packed collections of
    lymphocytes called follicles.                                     ______________________________
    c. Area of lymph node where a vessel exits.            ______________________________
    d. Outermost layer composed of connective tissue.  ______________________________
    e. Giant WBCs that destroy bacteria by phagocytosis.____________________________
    f. Most abundant cell type in a lymph node.            ______________________________
    g. Area in lymph node where lymphocytes multiply._____________________________
    h. Vessel that brings fluids into node.                      ______________________________    
    i. Specialized capillaries in nodes that slows fluid
    movement.                                                               ______________________________
    j. Vessel that exits from node.                                  _______________________________
    k. Inner matrix of reticular fibers.                             _______________________________

10. __a__, are a kind of WBC that arise in the bone marrow and then migrate to lymph nodes to concentrate
and multiply.  They multiply in areas of lymph nodes called __b__ at a rate of 10 million/day.  __a__ that
originate in the bone marrow are specifically called __c__ __a__.  __c__  __a__ divide rapidly in __b__ to
produce __d__ cells.  __d__ cells release __e__ that help your body mount an immune response to foreign matter.
    a. ______________________________        d. ______________________________
    b. ______________________________        e. ______________________________
    c. ______________________________    

11. List 5 other lymphoid organs besides lymph nodes.       
                                ______________________________
                                ______________________________
                                ______________________________
                                ______________________________
                                ______________________________

12.  All of the lymphoid organs listed in question #11 have 2 things in common.  Name them.
                            _____________________________________
                            _____________________________________
13. Identify the lymphoid organ based on the information given below.
    a. Largest lymphoid organ; fist-sized.                    _______________________________
    b. Deep to the sternum in mediastinum.                 _______________________________
    c. Ring of tissue around entrance to pharynx.        _______________________________
    d. Mass of lymphoid tissue at end of cecum.          _______________________________
    e. Large isolated clusters of lymphoid tissue in small
    intestine.                                                                 _______________________________
    f. Where T lymphocytes become immunocompetent. _____________________________
    g.  Prevents bacteria from entering through intestinal wall. _________________________
    h. Located in left abdominal cavity just beneath
    diaphragm.                                                              ______________________________

14. List 5 functions of the spleen.               
                                _______________________________
                                _______________________________
                                _______________________________
                                _______________________________
                                _______________________________

15.  Name and give the location of the 3 kinds of tonsils.
                            ______________________________________
                            ______________________________________
                            ______________________________________
16.  Why do lymph nodes swell during an illness? ____________________________________________
            ______________________________________________________________________________

17. _________________________ is a disease caused by parasitic worms blocking the lymph vessels and
nodes and preventing return of fluids back to main circulation.

18. _________________________ disease is a malignancy of the lymph nodes.  The nodes become swollen
and painful.

19. Why do people that have had a spleenectomy later have difficulty fighting infections? ____________
___________________________________________________________________________________
___________________________________________________________________________________

20. Elephantiasis is a parasitic disease where filarial worms live in the lymphatic system.  With a large
infestation, what symptoms would you expect to see? _______________________________________
__________________________________________________________________________________

21. What is chyle and why is it a different color from fluids normally found in the lymphatic vessels? ___
___________________________________________________________________________________
___________________________________________________________________________________

22. How are lymphatic capillaries designed for a one-way flow? ________________________________
___________________________________________________________________________________
___________________________________________________________________________________

23. Lymph nodes are designed to slow blood flow.  How and why do they accomplish this?  __________
___________________________________________________________________________________
___________________________________________________________________________________

Answers:  Worksheet V-Lymphatic System

1.  Lymphatic vessels and lymphatic organs.
2. Drains tissue spaces of protein containing fluid./Transports fats from digestive tract to the blood./
Produces lymphocytes for our immune system.
3. CNS,Bone,Cartilage,Epidermis,Teeth.
4.     a. lymph                    c. hydrostatic
        b. arterial
5. Lymphatic capillaries--Lymphatic collecting vessels--Lymphatic trunks--Lymphatic ducts.
6. a. lymphatic capillaries                h. lymphatic trunks
    b. endothelial                               i.   right lymphatic duct
    c. valves                                       j.  thoracic  duct
    d.  lacteals                                    k.  cisternae chyli
    e.  white                                       l. internal jugular (subclavian vein)
    f. fat                                            m. subclavian vein (internal jugular)
    g. lymphatic collecting vessels

7.  Massaged by skeletal muscles./Pressure changes in thorax./Valves./Smooth muscle in tunica media.

8.      a. 100's                        c. inguinal (axillary)
         b. axillary (inguinal)

9. a. medulla                    g. germinal centers
    b. cortex                      h. afferent vessel
    c. hilus                        i. sinusoids
    d. capsule                    j. efferent vessel
    e. Macrophages           k. stroma
    f. lymphocyte (B)

10.     a. Lymphocytes                    d. plasma
          b. germinal centers                e. antibodies
          c.  B

11.      Spleen, thymus, tonsils, Peyer's patches, appendix.

12.  Stroma of reticular fibers and large concentrations of lymphocytes.

13.      a. Spleen                      e. Peyer's patches
           b. Thymus                    f. Thymus
           c. Tonsils                      g. Peyer's patches
           d. Appendix                  h. Spleen

14.  Site for lymphocyte proliferation./Initiates immune response./Cleanses blood of old RBCs,
platelets, bacteria, and viruses./Stores products of RBC breakdown./Produces RBCs in the fetus./
Stores platelets.

15. Palatine-each side of posterior oral cavity; Lingual-at base of the tongue; Pharyngeal (= adenoids)-
posterior wall of nasopharynx.

16. Large amounts of cellular debri accumulate and slow fluid flow through nodes.
17. Elephantiasis
18. Hodgkin's
19.  The spleen is a site for lymphocyte proliferation and also cleans the blood of bacteria and viruses.

20.  Since the lymphatics return fluids from the interstitial spaces back to the main circulation, any blockage
would prevent this function.  This fluid, which is mainly water, accumulates between cells, and because
water is heavy, gravity forces it to accumulate in the lower body regions such as the feet and legs.  Additionally,
any loose or flexible tissues such as breast or scrotal skin will enlarge dramatically.

21. Chyle is lipid-rich lymph that forms from fat absorption in the small intestine.  The lymphatic capillaries, or
lacteals, of the small intestine pick up fat and deliver to the main circulation. Chyle is milky white because of the
high fat content.

22. Lymphatic capillaries posses valves anchored by protein filaments that allows them to only open inward. 
Lost interstitial fluids may enter, but not leave.

23. Externally, lymph nodes possess more afferent than efferent vessels.  Internally, they are compartmentalized by
trabeculae.  Slowing of lymph flow allows debri, toxins, viruses, and bacteria to be more completely filtered out of
the lymph fluid for its eventual return to the main circulation.

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