Worksheet IV:  Circulatory System-Vessels

1.   _________________________ proposed the existence of capillaries and outlined the circulation pattern we understand today.
2.  Name the 3 layers of arteries and veins from outermost to innermost.
                                ______________________________
                                ______________________________
                                ______________________________
3. The tunica media is divided into 2 layers; an outer layer of __a__ muscle innervated by the __b__ (Which ANS division?) and an inner layer of __c__ connective tissue.  This __c__ layer is much __d__ (larger/smaller) in arteries.
    a. ______________________________        c. ______________________________
    b. ______________________________        d. ______________________________
4. Identify the tunic of blood vessels based on the information given below.
    a. Vasa vasorum present.                _______________________________
    b. Composed of endothelium.                _______________________________
    c. Composed of simple squamous epithelium.        _______________________________
    d. Responsible for vasodilation and vasoconstriction.    _______________________________
    e.  Anchors and protects vessels.            _______________________________
    f. Composed of smooth muscle and elastic fibers.    _______________________________
    g. This tunic is absent in venules.            _______________________________
    h. This tunic is absent in arterioles.            _______________________________
    i. Only tunic present in capillaries.            _______________________________
5.  __a__ transport blood away from the heart and usually carry __b__ (oxygenated/deoxygenated) blood.  The exception to this pattern for __a__ is the __c__.  __d__ transport blood towards the heart and usually carry __e__ (oxygenated/deoxygenated) blood.  The __f__ is the exception to this pattern for __d__.
    a. ______________________________        d. ______________________________
    b. ______________________________        e. ______________________________
    c. ______________________________        f. ______________________________
6. Name the 3 kinds of arteries.                    ______________________________
                                ______________________________
                                ______________________________
7.  Identify the kind of artery based on the information given below.
    a. Contain elastic lamina.                ______________________________
    b. Thick-walled, large diameter, large amounts of elastic
    tissue.                            ______________________________
    c. Carry blood to specific organs; e.g. splenic, gastric,
    hepatic, etc.                        ______________________________
    d. Smallest in diameter; only 2 tunics.            ______________________________
    e. Lumen is less than 0.5 mm in diameter.        ______________________________
    f. Most important in vasoregulation.            ______________________________
    g. Tunica media is mostly smooth muscle; medium diameter. ___________________________
8. List 5 characteristics of veins.                _____________________________________
                            _____________________________________
                            _____________________________________
                            _____________________________________
                            _____________________________________
9. The largest veins are:                    ______________________________.

10. Dilated veins with malfunctioning valves are called __a__ veins.  __a__ veins of the anal canal are called __b__.  Give 3 factors that influence the formation of __a__ veins: __c__, __d__, and __e__.
    a. ______________________________        d. ______________________________
    b. ______________________________        e. ______________________________
    c. ______________________________    
11. List 3 kinds of capillaries.                    ______________________________
                                ______________________________
                                ______________________________



12. Identify the kind of capillary based on the information given below.
    a. Highly modified, very leaky capillaries in liver, marrow,
    and lymphoid tissues.                    ______________________________
    b. Important in slowing blood flow for processing.    ______________________________
    c. Endothelium cells united by tight junctions.        ______________________________
    d. Abundant in skin and muscles.            ______________________________
    e. Great permeability, endothelial cells riddled with pores. _____________________________
    f. Found where absorption occurs; e.g. small intestine,
    kidneys, and endocrine organs.                ______________________________
13.  An interweaving group of capillaries is called a(n) __a__.  The part of the __a__ where an artery connects directly to a vein is called the __b__.  Exchange of gases, nutrients, or wastes __c__ (does/does not) occur in __b__.  __d__, however, branch off the __b__ on the arteriole end and return to the __b__ at the venule end.  Gases, nutrients, and wastes __e__ (are/are not) exchanged in __d__.   __f__, smooth muscle valves, surround each root of a __d__ and regulate blood flow.
    a. ______________________________        d. ______________________________
    b. ______________________________        e. ______________________________
    c. ______________________________        f. _______________________________
14.  List 3 kinds of openings or transport methods in capillaries.    ______________________________
                                ______________________________
                                ______________________________
15. Give the mean pressure value for the vessels listed below.
                                Aorta __________________________
                                Arteries ________________________
                                Arterioles _______________________
                                Capillaries ______________________
                                Venules ________________________
                                Veins __________________________
                                Vena cavae _____________________
16. Name 4 factors that affect arterial (blood) pressure.        _______________________________
                                _______________________________
                                _______________________________
                                _______________________________
17.  Of the 4 factors listed in question #16, the most important is __a__.  __a__ is the most important because __a__ varies inversely with the 4th power of the vessel __b__.  Therefore, small changes in __c__ can produce __d__ changes in __a__.
    a. ______________________________        c. ______________________________
    b. ______________________________        d. ______________________________
18.  __a__ is defined as the amount of pressure exerted on the inside of a vessel wall.  __b__ directly affects __a__ because __a__ is equal to __b__ times peripheral resistance.  If __b__ is increased and peripheral resistance is held constant, then __a__ will __c__ (increase/decrease/remain unchanged).
    a. ______________________________        c. ______________________________
    b. ______________________________    

19. If blood volume is __a__ (increased/decreased/not affected) because of hemorrhage or dehydration then blood pressure will __b__ (increase/decrease/not be affected).
    a. ______________________________        b. ______________________________

20. If blood viscosity is __a__ (increased/decreased/not affected) because of polycythemia then blood pressure will __b__ (increase/decrease/not be affected).
    a. ______________________________        b. ______________________________











21.  Many factors control blood pressure. __a__ or local controls make automatic adjustments in blood flow in direct proportion to requirements.  Organs regulate their own blood flow by vasoconstriction or vasodilation.  Receptors for stretch, pH, and chemicals use reflex arcs to make adjustments in pressure. In general, receptors send information via __b__ neurons to the __c__ center in the medulla.  __d__ neurons send messages out to __e__ effectors in blood vessels.  Specifically, increased vessel diameter activates __f__ which __g__ (increases/decreases) the number of impulses going to the __c__ center.  The __c__ center __h__ (excites/inhibits) __d__ neurons going to __e__ effectors (muscle type) and this causes __i__ (vasoconstriction/vasodilation) and as a result __j__ (increases/decreases) blood pressure.  The __c__ works via reflex, but can also be modified by higher brain centers such as the __k__ and __l__.
    
    a. ______________________________        g. ______________________________
    b. ______________________________        h. ______________________________
    c. ______________________________        i. _______________________________
    d. ______________________________        j. ______________________________
    e. ______________________________        k. ______________________________
    f. ______________________________        l. _______________________________
22. __a__ receptors detect changes in blood oxygen or pH.  These receptors are found in the __b__ and __c__ bodies.  These receptors are less important in modifying blood pressure, but are more important in modifying the rate and depth of __d__.
    a. ______________________________        c. ______________________________
    b. ______________________________        d. ______________________________
23.  Name 7 chemicals that affect blood pressure, tell whether they increase or decrease blood pressure, and how they initiate the change.                                    Chemical           Change caused if released        How effect is caused. ____________________      _____________________     ___________________________________
____________________      _____________________     ___________________________________
____________________      _____________________     ___________________________________
____________________      _____________________     ___________________________________
____________________      _____________________     ___________________________________
____________________      _____________________     ___________________________________
____________________      _____________________     ___________________________________

24.  The __a__ (Give organ.) controls blood pressure by tubular reabsorption and secretion. It also can control BP by releasing the hormone __b__.
    a. _______________________________    b. ________________________________
25.  Name 4 forces that move substances across a capillary's endothelium.
                                _______________________________
                                _______________________________
                                _______________________________
26. What 3 categories of substances move across a capillary wall by diffusion?
                                _______________________________
                                _______________________________
                                _______________________________

27. Identify the forces that move fluids across the capillary endothelium based on the information given below.
    a. Force caused by large nondiffusible substances in fluids. _____________________________
    b. Force or pressure exerted by the interstitial fluids outside
    of capillaries.                        _______________________________
    c. Force exerted by a fluid pressing against (from inside
    out) a vessel wall.                    _______________________________
    d. Force created by albumins in plasma of capillaries.    _______________________________
    e. Force created by solutes present in interstitial fluids.    _______________________________
28. Answer the following questions about fluid movements in a capillary.
    a. Capillary hydrostatic pressure (HPc) at the arterial end
    of a capillary.                        _______________________________
    b. HPc at the venous end of a capillary.            _______________________________
    c. Direction (into capillary or out of capillary) that fluids
    are forced by HPc-arterial end.                _______________________________
    d.  Direction (into capillary or out of capillary) that fluids
    are forced by HPc-venous end.                _______________________________
    e. Interstitial fluid hydrostatic pressure (HPif) at the arterial
    end of a capillary.                    _______________________________
    f. HPif at the venous end of a capillary.            _______________________________
    g. Direction (into capillary or out of capillary) that fluids
    are forced by HPif-arterial end.                _______________________________
    h.  Direction (into capillary or out of capillary) that fluids
    are forced by HPif-venous end.                _______________________________
    i. Net hydrostatic pressure (HPnet) at the arterial end
    of a capillary.                        _______________________________
    j. HPnet at the venous end of a capillary.            _______________________________
    
    k. Direction (into capillary or out of capillary) that fluids
    are forced by HPnet-arterial end.            _______________________________
    l.  Direction (into capillary or out of capillary) that fluids
    are forced by HPnet-venous end.            _______________________________
    m. Osmotic pressure (OPc) in the capillary.        _______________________________
    n.  OP of the interstitial fluids (OPif).            _______________________________
    o.  OPnet along the capillary.                _______________________________
    p.  Direction (into capillary or out of capillary) that fluids
    are forced by OPnet.                    _______________________________
    q.  Fluids will leave capillaries if:                _______________________________
    r. Is HP greater than or less than OP at the arterial end?  _______________________________
    s. Refer to r. Which direction do fluids move at the arterial
    end of the capillary?                     _______________________________
    t. Is HP greater than or less than OP at the venous end?  _______________________________
    u. Refer to t.  Which direction do fluids move at venous
    end of the capillary?                     _______________________________
    v. Therefore there is net a fluid loss at the (arterial or
    venous end):                        _______________________________
    w. Lost fluids are returned to main circulation by the:    _______________________________
29. How does the aorta act as a second heart? _____________________________________________
___________________________________________________________________________________

30.  Outline the reflex arc for vasomotor control. ____________________________________________
___________________________________________________________________________________

31.  What is the difference between hydrostatic and osmotic pressures? __________________________
___________________________________________________________________________________

32. Why would a soldier be told to wiggle his toes in his boots when he is standing at attention for a long period of time? _______________________________________________________________________
___________________________________________________________________________________
___________________________________________________________________________________

33.  Why do veins tend to collapse more than arteries when they are placed on a slide? _____________
___________________________________________________________________________________

34. What kind of problems would a person with diabetes insipidus have with his blood pressure? Why?
___________________________________________________________________________________
___________________________________________________________________________________
___________________________________________________________________________________

35. How would a high salt diet affect hydrostatic pressure and what problems would this cause? _______
___________________________________________________________________________________
___________________________________________________________________________________

36. How are thoroughfare channels important in regulating blood flow? ___________________________
___________________________________________________________________________________
___________________________________________________________________________________



37. Which is the most important factor affecting arterial pressure?  Why? _________________________ ___________________________________________________________________________________
___________________________________________________________________________________
___________________________________________________________________________________

38. Excluding the heart, which is the most important organ affecting blood pressure? Why? ___________
___________________________________________________________________________________
___________________________________________________________________________________

39. How would polycythemia vera affect blood pressure? Why? ________________________________
___________________________________________________________________________________
___________________________________________________________________________________

40.  How can long term exercise actually  lower one's blood pressure? ___________________________
___________________________________________________________________________________
___________________________________________________________________________________




































Answers:  Worksheet IV-Vessels.

1.  William Harvey
2. Tunica adventitia (externa), tunica media, tunica intima (endothelium).
3.     a. smooth                    c. elastic    
    b. Sympathetic NS                d. larger

4.     a. Tunica externa                f. Tunica media
    b. Tunica intima                    g. Tunica media
    c. Tunica intima                    h. Tunica externa
    d. Tunica media                    i. Tunica intima
    e. Tunica externa

5.     a. Arteries                    d. Veins
    b. oxygenated                    e. deoxygenated
    c. pulmonary artery                f. pulmonary vein
6. Elastic, muscular, arterioles
7.     a. Elastic                    d. Arterioles
    b. Elastic                    e. Arterioles
    c. Muscular                    f. Arterioles
                            g. Muscular
8.  Trasnport blood to the heart/Usually deoxygenated/Low pressure/Thin walled and large diameter/Valves present.
9. Vena cavae
10.     a. varicose                    d. Pregnancy
    b. hemorrhoids                    e. Long periods of standing
    c. Obesity
11. Continuous/Discontinuous (fenestrated)/Sinusoids
12.     a. Sinusoid                    d. Continuous
    b. Sinusoid                    e. Discontinuous
    c. Continuous                    f. Discontinuous

13.     a. capillary bed                    d. True capillaries
    b. thoroughfare channel                e. are
    c. does not                    f. Precapillary sphincters
14. Intercellular clefts/Pinocytic vesicles/Membrane pores.
15.     aorta-between 90 and 120/arteries-betw 80 and 110/arterioles-betw 60 and 80/capillaries-betw 20 and 40/venules-betw 15 and 20/veins-betw 5 and15/vena cavae-between 2 and 5.  All values in mmHg.
16. Cardiac output/Blood volume/Peripheral resistance/Viscosity
17.     a. peripheral resistance                c. diameter (radius)
    b. radius                    d. large


18.     a. Blood pressure                c. increase
    b. Cardiac output

19.     a. decreased                    b. decrease

20.     a. increased                    b. increase (The heart has to work harder to                                 move thicker blood.)
21.     a. Autoregulation                g. increases
    b. sensory                    h. inhibits
    c. vasomotor                    i. vasodilation
    d. motor                    j. decreases
    e. smooth muscle                k. cerebral cortex (hypothalamus)
    f. mechanoreceptors (baroreceptors or        l. hypothalamus (cerebral cortex)
         pressoreceptors)

22.     a. Chemoreceptors                c. aortic (carotid)
    b. carotid (aortic)                d. breathing
23. Angiotensin II, increases BP, by vasoconstriction/Vasopressin, increases BP, by vasoconstriction/E, increases BP, by increasing heart rate and vasoconstriction/NE-basically the same as E/Atrial natriuretic factor, decreases BP, by increasing Na+ excretion and therefore water loss, water loss decreases blood volume which decreases BP/Aldosterone, increases BP, increases Na+ absorption causing water retention which increases blood volume which increases BP/ADH, increases BP, by causing kidneys to conserve water which raises blood volume which increases BP.
24.     a. kidney                    b. renin
25. diffusion, endocytosis, exocytosis, hydrostatic pressure
26. lipid-soluble, water, and water soluble substances
27.    a. Osmotic pressure                d. Osmotic pressure in capillaries OPc
    b. Interstitial fluid hydrostatic pressure (HPif)    e. Osmotic pressure in interstitial fluid (OPif)
    c. Hydrostatic pressure of capillary (HPc)

28.     a.  32 mmHg                    m. 25 mmHg
    b. 15 mmHg                    n.  3 mHg
    c. fluids forced out of capillary by HP        o.  25 - 3  =  22 mmHg
    d. fluids forced out of capillary by HP        p. Fluids pulled back into capillary by OP
    e. difficult to measure, probably negative but    q. netHP > net OP
    we will use 0.                    r. HP > OP arterial end
    f. same as in e.                    s. Fluids are forced out of capillary at arterial     g. Fluid movement not affected if value is 0,    end.
    but will be pulled out if negative.            t. HP < OP venous end
    h. Same as in g.                u. Fluids are pulled back into capillary at
    i. netHPart end  = 32 - 0  = 32 mmHg        venous end.
    j. netHPven end = 15 - 0  = 15mmHg        v. arterial end
    k. Forces fluids out of capillary at arterial end.    w. lymphatic system
    l. Forces fluids out of capillary at venous end.
29. The aorta is an elastic artery. The elastic stretches with each ventricular contraction and ,as a stretched rubber band would do when the tension is released, the artery recoils and pushes the blood onward.
30. Baroreceptor---sensory neuron---vasomotor center in medulla--motor neurons (ANS)--smooth muscle effector in vessel wall.
31. Hydrostatic pressure is the force exerted by a liquid outward on the inner wall of a vessel (or even your garden hose) while osmotic pressure is caused by differences in solute concentrations on each side of a membrane.  Water is pulled from a hypotonic area to a hypertonic area. The force that the moving water exerts on a cell membrane is osmotic pressure.
32. Without the skeletal muscles massaging the veins that return blood from the lower body, evntually blood begins to pool in the lower body and away from the brain.  The brain is deprived of oxygen, the person faints, and blood flow returns to normal.
33.

* For question 28, pressure values vary.  Therefore, you could easily come up with different numerical values and be correct.  Just be consistent on what source you use and whatever numbers you obtain. They should be in the same general direction and produce the same general results as the numbers I have used.